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Kindly provide clinical studies on the benefits of Vitamin A, C and E for skin health.

July 15, 2020
ANSWER

Vitamins A, C and E have demonstrated efficacy in improving both the health and appearance of the skin. They provide structural integrity and biological function to protect the skin from damage, address common skin concerns and have antiaging effects (Park, 2015).

Clinical Studies of Vitamins for Skin Health:-

Reference
Vitamins
Findings and Outcome
Al-Niami & Chiang, 2017
Vitamin C
Protect against photoaging, ultraviolet-induced immunosuppression, and photocarcinogenesis.
Antiaging effect by increasing collagen synthesis, stabilizing collagen fibers, and decreasing collagen degradation.
Decreases melanin formation, thereby reducing pigmentation
Bertuccelli et al., 2016
Vitamin C
Improved skin tightness in individuals due to loss of elastin and collagen fibres, thinning of skin layers and loss of muscle tone
Costa et al., 2015
Vitamin C
Improvement in erythema, hydration, radiance, and overall appearance. Decreased intensity of general skin spots, UV spots, and brown spots, improved skin texture and appearance of pores.
Increased collagen (43%–57%) and elastin (20%–31%).
Keen & Hassan, 2016
Vitamin E
Protects the skin from various harmful effects due to solar radiation by acting as a free‑radical scavenger thus promoting healthy skin
Kim et al., 2016
Mitochondria-targeted vitamin E (MVE)
Enhance skin healthiness by protecting dermal fibroblasts and epidermal of skin from UVB irradiation as well increased collagen production
Schagen et al., 2012
Vitamin E
Helps against collagen cross linking and lipid peroxidation, which are both linked to aging of the skin.
Al-Niami & Chiang, 2017
Vitamin C and E
Vitamin C is the primary replenisher of vitamin E and works synergistically with vitamin E in the protection against oxidative damage to the skin
Rattanawiwatpong et al., 2020
group  of  50  Thai  women  with
Fitzpatrick skin type III or IV, mean age 47 years
Vitamin C and E
Improve most sign of skin aging, skin darkening, elasticity, radiance, smoothness, scaliness and wrinkles
Zasada & Budzisz, 2019
Vitamin A
Anti-wrinkle treatments, improvement of texture, dyspigmentation, acne, dryness, and fine lines. Restrain transepidermal water loss and protect collagen against degradation
Shao et al., 2017
Vitamin A – Retinoids (Retinol & Retinoic acid)
Treatment for skin aging (increased epidermal thickness, stimulating the proliferation of keratinocytes, endothelial cells, and activating dermal fibroblasts (Type 1 collagen, elastin)

 

References

Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of clinical and aesthetic dermatology, 10(7), 14–17.

Bertuccelli, G., Zerbinati, N., Marcellino, M., Nanda Kumar, N. S. He, F., Tsepakolenko, V., Cervi, J., Lorenzetti, A., & Marotta, F. (2016). Effect of a quality-controlled fermented nutraceutical on skin aging markers: An antioxidant-control, double-blind study. Journal Experimental and Therapeutic Medicine, 11(3), 909–916. https://doi.org/10.3892/etm.2016.3011

Costa, A., Pegas Pereira, E. S., Assumpção, E. C., Calixto Dos Santos, F. B., Ota, F. S., de Oliveira Pereira, M., Fidelis, M. C., Fávaro, R., Barros Langen, S. S., Favaro de Arruda, L. H., & Abildgaard, E. N. (2015). Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men. Clinical, Cosmetic and Investigational Dermatology, 8, 319–328. https://doi.org/10.2147/CCID.S79447

Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal, 7(4), 311–315. https://doi.org/10.4103/2229-5178.185494

Kim, W. S., Kim, I., Kim, W. K., Choi, J. Y., Kim, D. Y., Moon, S. G., Min, H. K., Song, M. K., & Sung, J. H. (2016). Mitochondria-Targeted Vitamin E Protects Skin from UVB-Irradiation. Biomolecules & Therapeutics Journal, 24(3), 305–311. https://doi.org/10.4062/biomolther.2015.131

Park K. (2015). Role of micronutrients in skin health and function. Biomolecules & Therapeutics Journal, 23(3), 207–217. https://doi.org/10.4062/biomolther.2015.003

Rattanawiwatpong, P., Wanitphakdeedecha, R., Bumrungpert, A., & Maiprasert, M. (2020). Anti‐aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split‐face, randomized controlled trial. Journal of Cosmetic Dermatology. 19(3), 671-676. https://doi.org/10.1111/jocd.13305

Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-Endocrinology, 4(3), 298-307. https://doi.org/10.4161/derm.22876

Shao, Y., He, T., Fisher, G. J., Voorhees, J. J., & Quan, T. (2017). Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo. International Journal Of Cosmetic Science, 39(1), 56–65. https://doi.org/10.1111/ics.12348

Zasada, M., & Budzisz, E. (2019). Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy Dermatologiy and Allergology Journal, 36(4), 392–397. https://doi.org/10.5114/ada.2019.87443