Question

If I would like use HSI plus Zinc and want to claim this product can support the immune system. How many dosage that has effective with studies?

ANSWER

Inulin is non-digestible prebiotic fibre that stimulates the growth of good bacteria which enhance the development of immune system and intestinal function (Lockyer & Stanner, 2019; Gibson, et al., 2017).

Table A. Dosage of Inulin Consumption on Subject Groups for Immunity Effects

Reference Dosage Subject Groups Findings on Immunity Effects
Oswari et al., 2019 3.2 g/day inulin Infants Increase in bifidogenic effect, stool frequency and decrease in stool pH
Lohner et al., 2018 6 g/day
(Orafti® Inulin)
Children 3 to 6 year Softer stools, higher counts of beneficial bacteria (Bifidobacterium and Lactobacillus) in stools, and fewer fevers requiring medical attention.
Stephan & Carolin, 2018 6 g/day (mix of 93% of Orafti® HSI and 7% Orafti® HP) Children 3 to 6 years Improve performance of the

immune system by reduction the sinusitis symptoms in children

Azpiroz et al., 2017 8 g/day (Orafti HSI Inulin) Patients (20 to 70 years) with moderate

abdominal discomfort

Promote the proliferation of bifidobacteria which are able to ferment residues using metabolic pathways with lower gas release thus improves gut function
Micka et al., 2016 12 g/day (Orafti® Inulin) Healthy men and women aged ≥ 20 and ≤ 75 years Increase of stool frequency accompanied by a softening of stool consistency
Vandeputte et al., 2017 12 g/day (Orafti® Inulin) Healthy adults with mild constipation Increase in stool frequency resulting from inulin consumption which support digestive health
EFSA, 2015 12 g/day (Orafti® Inulin) Six  studies  involving  86  subjects Improves bowel function by increasing stool frequency

 

Zinc is one of the micronutrients that promotes immunity that plays an important role in the development and integrity of the immune system (Gombart et al., 2020).

Table B. Dosage of Zinc Consumption on Subject Groups for Immunity Effects

Reference Dosage Subject Groups Findings on Immunity Effects
Gulani et al., 2014 5 – 50 mg/day Children and young adults Reduce the incidence of otitis media infections in younger or undernourished children
Hemilä (2011) > 75 mg/day Children and adults Reduced common cold
Mocchegiani et al., 2013 10 – 12 mg/day Elderly people Enhance immunity in older people by preventing the risk of degenerative age-related diseases, such as cancer and infection
Malik et al., 2014 20 mg/day Children aged 6-11 months with acute respiratory infections Reduced acute lower respiratory tract infection morbidity

 

References

Azpiroz, F., Molne, L., Mendez, S., Nieto, A., Manichanh, C., Mego, M., Accarino, A., Santos, J., Sailer, M., Theis, S., & Guarner, F. (2017). Effect of chicory-derived inulin on abdominal sensations and bowel motor function. Journal of Clinical Gastroenterology, 51(7), 619–625. https://doi.org/10.1097/MCG.0000000000000723

EFSA, (2015). Scientific Opinion on the substantiation of a health claim related to “native chicory inulin” and maintenance of normal defecation by increasing stool frequency pursuant to Article 13.5 of Regulation (EC) No 1924/2006. EFSA Panel on Dietetic Products Nutrition and Allergies (NDA). EFSA Journal, 13(1), 3951. https://doi.org/10.2903/j.efsa.2015.3951

Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K., & Reid, G. (2017). Expert consensus document: The international scientific association for probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology. 14(8), 491-502. https://doi.org/10.1038/nrgastro.2017.75

Gombart, A. F., Pierre, A., & Maggini, S. (2019). Settings. A review of micronutrients and the immune system–working in harmony to reduce the risk of infection. Nutrients, 12(1), 236.  https://doi.org/10.3390/nu12010236

Gulani, A. & Sachdev, H. S. (2014). Zinc supplements for preventing otitis media. Cochrane Database Systematics Reviews. 4, 29(6). https://doi.org/10.1002/14651858.CD006639.pub4

Hemilä, H. (2011). Zinc lozenges may shorten the duration of colds: a systematic review. Open Repspiratory Medicine Journal, 5, 51-8. https://doi.org/10.2174/1874306401105010051

Lockyer, S., & Stanner, S. (2019). Prebiotics – an added benefit of some fibre types. Nutrition Bulletin, 44, 74-91. https://doi.org/10.1111/nbu.12366

Lohner, S., Jakobik, V., Mihályi, K., Soldi, S., Vasileiadis, S., Theis, S., Sailer, M., Sieland, C., Berényi, K., Boehm, G., & Decsi, T. (2018). Inulin-type fructan supplementation of 3- to 6-year-old children is associated with higher fecal Bifidobacterium concentrations and fewer febrile episodes requiring medical attention. The Journal of Nutrition, 148(8), 1300–1308. https://doi.org/10.1093/jn/nxy120

Lohner, S., Jakobik, V., Mihályi, K., Soldi, S., Vasileiadis, S., Theis, S., Sailer, M., Sieland, C., Berényi, K., Boehm, G., & Decsi, T. (2018). Inulin-type fructan supplementation of 3- to 6-year-old children is associated with higher fecal Bifidobacterium concentrations and fewer febrile episodes requiring medical attention. The Journal of Nutrition, 148(8), 1300–1308. https://doi.org/10.1093/jn/nxy120

Malik, A. Taneja, D.K.; Devasenapathy, N.; Rajeshwari, K. (2014). Zinc supplementation for prevention of acute respiratory infections in infants: A randomized controlled trial. Indian Pediatric Journal. 51, 780–784.

Micka, A., Siepelmeyer, A., Holz, A., Theis, S., & Schön, C. (2016). Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. International Journal of Food Sciences and Nutrition, 68(1), 82–89. https://doi.org/10.1080/09637486.2016.1212819

Mocchegiani, E., Romeo, J., Malavolta, M., Costarelli, L., Giacconi, R., Diaz, L. E., & Marcos, A. (2013). Zinc: dietary intake and impact of supplementation on immune function in elderly. Age (Dordrecht, Netherlands), 35(3), 839–860. https://doi.org/10.1007/s11357-011-9377-3

Oswari, H., Widodo, A. D., Handayani, F., Juffrie, M., Sundjaya, T., Bindels, J., & Hegar, B. (2019). Dosage-related prebiotic effects of inulin in formula-fed infants. Pediatric Gastroenterology, Hepatology & Nutrition, 22(1), 63-71. https://doi.org/10.5223/pghn.2019.22.1.63

Stephan, T. & Carolin, S. (2018). Prophylactic use of inulin against sinusitis. European patent No. EP3331537B1. Südzucker AG, Mannheim. European Patent Office.

Vandeputte, D., Falony, G., Vieira-Silva, S., Wang, J., Sailer, M., Theis, S., Raes, J. (2017). Prebiotic inulin-type fructans induce specific changes in the human gut microbiota. Gut, 66(11), 1968–1974. https://doi.org/10.1136/gutjnl-2016-313271

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